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Human Thyroglobulin
Thyroglobulin, TGN, AITD3, TG
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01266 |
|---|---|
| Calculated MW | 331 kDa |
| Gene ID | 7038 |
|---|---|
| Other Names | Thyroglobulin, TGN, AITD3, TG |
| Gene Source | Human |
| Source | N/A |
| Assay&Purity | SDS-PAGE;> 95% |
| Recombinant | No |
| Target/Specificity | TG |
| Format | Liquid |
| Storage | -20°C;N/A |
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Provided below are standard protocols that you may find useful for product applications.
Background
Thyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen.
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