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>   home   >   Products   >   Proteins   >   Human CellExp™ Gremlin / GREM1, Human recombinant   

Human CellExp™ Gremlin / GREM1, Human recombinant

GREM1, CKTSF1B1, DAND2, DRM, PIG2

     
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Product info
Primary Accession O70326
Calculated MW 20.2 kDa
Additional Info
Gene ID 23892
Other Names GREM1, CKTSF1B1, DAND2, DRM, PIG2
Gene Source Human
Source HEK 293 cells
Assay&Purity SDS-PAGE;> 95%
Recombinant Yes
Target/Specificity Grem1
Application Notes Reconstitute in sterile deionized water to the desired protein concentration.
Format Lyophilized
Storage -20°C;Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
Citations (0)

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Background

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

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$ 95.00
$ 395.00
Cat# PBV11604r-10
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