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Human CellExp™ VAPB, Human recombinant
VAPB, ALS8, VAMP-B, Vesicle-associated membrane protein-associated protein B/C
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95292 |
|---|---|
| Calculated MW | 15.8 kDa |
| Gene ID | 9217 |
|---|---|
| Other Names | VAPB, ALS8, VAMP-B, Vesicle-associated membrane protein-associated protein B/C |
| Gene Source | Human |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE;> 95% |
| Recombinant | Yes |
| Target/Specificity | VAPB |
| Application Notes | Reconstitute in sterile deionized water to the desired protein concentration. |
| Format | Lyophilized |
| Storage | -20°C;Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Vesicle-associated membrane protein-associated protein B/C (VAPB) is also known as VAMP-associated protein B/C (VAMP-B/VAMP-C or VAP-B/VAP-C), which is a single-pass type IV membrane protein and belongs to the VAMP-associated protein ( VAP ) family. Involved in cellular calcium homeostasis regulation, VAPB participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity as well. VAPB can interact with VAMP1, VAMP2, HCV NS5A, NS5B, ZFYVE27 (via MSP domain) and RMDN3. Human VAPB is involved in hepatitis C virus replication through interaction with NS5A and NS5B.
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