|Other Accession||Q9R171, P63182, P86437, P23435|
|Calculated MW||1632.69 Da|
|Other Names||Cerebellin-1, Precerebellin, Cerebellin, CER, [des-Ser1]-cerebellin, Cbln1|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Cerebellin is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity).|
|Cellular Location||Secreted. Cell junction, synapse, postsynaptic cell membrane|
|Tissue Location||Localized in the Purkinje cells. Cerebellin and [des-Ser1]-cerebellin are equally abundant|
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