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E7 (43 - 77), HPV Oncoprotein

Synthetic Peptide

     
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Product Information
Primary Accession P03129
Peptide ID 9042302
Calculated MW 3980.6 Da
Sequence NH2-GQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIR-COOH
Additional Information
Gene ID 1489079
Other Names Protein E7, E7
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name E7 {ECO:0000255|HAMAP-Rule:MF_04004}
Function Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.
Cellular Location Host cytoplasm {ECO:0000255|HAMAP- Rule:MF_04004, ECO:0000269|PubMed:18996550, ECO:0000269|PubMed:3033296}. Host nucleus {ECO:0000255|HAMAP- Rule:MF_04004, ECO:0000269|PubMed:18996550}. Note=Predominantly found in the host nucleus. {ECO:0000255|HAMAP-Rule:MF_04004, ECO:0000269|PubMed:18996550}
Research Areas
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Cat# SP2257a
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